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Beilstein J. Org. Chem. 2013, 9, 503–509, doi:10.3762/bjoc.9.54
Graphical Abstract
Figure 1: Biologically active 1,2,4-benzothiadiazine 1,1-dioxide derivatives.
Scheme 1: Retrosynthesis analysis of RSV inhibitors.
Scheme 2: Preparation of 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxide. Reagent and conditions: (i) (COCl)2, DM...
Scheme 3: Rationalization of the formation of compound 13.
Scheme 4: Preparation of benzothiadiazine-3-one 1,1-dioxide derivatives by acid-catalyzed hydrolysis; reagent...